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They can occur when a person eats more of an edible than is recommended, unaware that edibles can take up to an hour to take effect, compared to smoking marijuana which can take effect in minutes

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Toxicol Appl Pharmacol 96:1423 Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle