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Their proposed mechanisms of action include the promotion of angiogenesis, modulation of inflammatory cascades, and enhancement of tissue repair through multiple cellular pathways

Shift to green or brown, visible precipitate, or a metallic or ammonia-like smell indicates oxidation or copper dissociation

Forkhead Box O3 (FOXO3), an important transcription factor, reduces lipid peroxidation and intracellular iron accumulation by upregulating antioxidant genes and inhibiting the NF-B/MAPK signaling pathway, thereby lessening chondrocyte ferroptosis and ECM degradation (Zhao et al., 2023)

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