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Activation of MC1R on melanocytes stimulates melanin production and distribution, resulting in increased skin pigmentation even without UV exposure [2]

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Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte loss

By pre-mixing 'light' labelled samples with 'heavy' labelled standards prior to analysis, any potential matrix effects are compensated for, since each analyte/internal standard pair is similarly affected by the sample matrix