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The parent BPC protein was first isolated and characterized in the early 1990s by Predrag Sikiric and colleagues at the University of Zagreb

Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis

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