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18 Sequence analysis Amino acid sequences were selected from NCBI and UniProtKB databases: Homo sapiens (code: P09211), Bos taurus (code: NP_803482.1), Capra hircus (code: Q9TTY8.2), Equus caballus (code: XP_001498156.1), Ovis aries (code: XP_004019771.1) and Sus scrofa (code: M3V836)

Metal-based nanozymes Copper CuxO nanoparticle clusters containing phenylalanine have been shown to carry out multiple superoxide dismutase, catalase, glutathione peroxidase, and peroxidase-mimicking enzymes (Hao et al

Additionally, we explore an alternative delivery method involving gene therapy vectors (currently FDA-approved for other indications) as well as testing in human ROs