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Additionally, lactate treatment has been observed to enhance the expression of hypoxia-inducible factor (HIF)-1, PD-L1, and H3K18 acetylation in PCa cells, which in turn promote tumor angiogenesis (144)
[DOI] [PubMed] [Google Scholar] Harding SD, Sharman JL, Faccenda E, Southan C, Pawson AJ, Ireland S et al (2018)