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No study has tested these three together in animals or humans, so the synergy is reasoned from mechanism, not measured

1060 , 1061 For example, modeling by the RAND Corporation in 2017 showed that with an antiamyloid therapy for people in the MCI and early dementia stages of the disease, approximately 2.1 million individuals with MCI due to Alzheimer's disease would develop Alzheimer's dementia between 2020 and 2040 while on waiting lists for treatment