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doi: 10.1210/jc.2017-00696 108 UntermanTGPhillipsLS

However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

The sulfonic acid replacement by a carboxylic acid ( 34 ) maintained a good solubility but led to a substantial loss of binding activity in the CPMG assay (Table 1)