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Description

Animal studies using the gold-standard euglycemic clamp technique confirmed that even chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity, despite significant fat loss occurring

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MYCN abundance modestly influenced sensitivity: MYCN downregulation in IMR-5/75 cells slightly reduced toxicity, while MYCN induction in SH-SY5Y/MYCN slightly increased it, though neither change reached significance

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